MYOC Glaucoma
DEDICATED TO DISCOVERING THE CAUSES AND THE CURES FOR GLAUCOMA
LAB NEWS
Lab publishes report linking ocular endothelin levels with galucoma
Endothelin is a potent vasoconstrictor and may have a role in vascular causes of glaucoma.
Dr. John Fingert, Dr. Adam Buenz-Hedberg, and Angela Nyunt teamed up with glaucoma surgeons Dr. Erin Boese, Dr. Andrew Pouw, and Dr. Nathan Sears to study the levels of endothelin in aqueous humor of glaucoma patients undergoing surgery.
They detected a significant increase in endothelin levels in glaucoma patients, suggesting this molecule may contribute to glaucoma pathogenesis. Read more about about this research in their BMC Ophthalmology report.
OUR MAJOR PROJECTS
TBK1 GENE
AND NORMAL TENSION GLAUCOMA
We discovered that TBK1 gene duplications or triplications are one of the most common known causes of normal tension glaucoma. We continue to study how mutations in TBK1 cause glaucoma using human donor eyes, stem cell biology, and transgenic animals. Read more about this research here.
OUR PUBLICATIONS
Click here to see all of our publications on PUBMED
Select publications described below:
OUR MAJOR DISCOVERIES
• Discovery of the first glaucoma gene (MYOC)
• Discovery of a low pressure glaucoma gene (TBK1)
• Engineering transgenic mice that develop low pressure glaucoma due to TBK1 gene mutation
• Creating induced pluripotent stem cells (iPSCs) with TBK1 mutations
• First genetic studies of Ocular Hypertension Treatment Study (OHTS)​
• First Exome study of Pigmentary Glaucoma