In a world-wide collaboration, we used genome-sequencing approaches to precisely define the extent and organization of TBK1 gene duplications and triplications in glaucoma patients. Read more about it here.
Fingert Lab NewsThursday, December 7, 2017 - 07:15
Fingert Lab NewsWednesday, July 26, 2017 - 14:45
The Glaucoma Genetics Lab joined Tin Aung, CC Khor, and our colleagues around the world in conducting a genome-wide association study (GWAS) of exfoliation syndrome and glaucoma. This huge multi-center study of 13,620 patients and 109,837 control subjects identified five new genetic risk factors for exfoliation syndrome: POMP, TMEM136, AGPAT1, RBMS3, and SEMA6A. Read more about this discovery here (11.8 MB).
Fingert Lab NewsWednesday, July 12, 2017 - 16:00
We recently published a report about the different types of inherited glaucoma that have an onset during childhood. Read more about this report here.
Fingert Lab NewsThursday, March 30, 2017 - 12:15
The Glaucoma Genetics Lab discovers mutation of the TP63 gene in a patient with Lacrimo-Auriculo-Dento-Digital (LADD) syndrome, which is a condition that causes malformation of ears, teeth, and hands as well as problems with tear formation and dry eye. In this manuscript, we report the genetic cause of the first case of LADD syndrome with glaucoma and thin corneas. Read more about this discovery here.
Fingert Lab NewsFriday, February 17, 2017 - 21:45
Fingert Lab NewsSaturday, December 24, 2016 - 18:45
We recently showed that duplication of the TBK1 gene causes human glaucoma that occurs at low intraocular pressure. In this study, we engineered mice to have an extra copy of the TBK1 gene in its genome. These mice develop glaucoma that occurs at normal eye pressures, just like the glaucoma in our patients with a TBK1 gene duplication. The results of this study provide the strongest proof that mutations in the TBK1 gene cause human glaucoma and the mice will be a powerful resource for studying the causes and testing cures for human glaucoma. Read more about this research here.
Fingert Lab NewsSaturday, December 17, 2016 - 14:30
The lab’s most recent publication shows that MMP19 protease is produced in human optic nerve, where its enzymatic function may have a role in the damage to the optic nerve that occurs in cavitary optic disc anomaly and glaucoma. Read more about it here.
Fingert Lab NewsFriday, December 2, 2016 - 08:00
Dr. Fingert recently became a member of the American Ophthalmological Society (AOS), a professional association that is committed to "the advancement of ophthalmic science and art.” Read Dr. Fingert’s AOS thesis here.
Fingert Lab NewsWednesday, October 26, 2016 - 17:45
Glaucoma Center faculty Dr. Wallace LM Alward and John H Fingert discuss genetic testing and glaucoma in an article by the American Academy of Ophthalmology’s EyeNet. Read the article here.
Fingert Lab NewsMonday, October 3, 2016 - 09:00
Our genetic analysis of the Ocular Hypertension Treatment Study (OHTS) investigated the effect of genetic risk factors on the probability of participants with high intraocular pressure going on to develop glaucoma. We found that OHTS participants that carry a genetic risk factor in the TMCO1 gene have a significantly higher probability of developing glaucoma. Read more about this study here.